SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure

Table 1

Effect of Atp2a2 heterozygosity on regulators of apoptosis and energy metabolism in DCM and DCM/HET hearts.

Gene	Relative mRNA levels (normalized to Gapdh)
	WT	DCM	DCM/HET
CHOP (Ddit3)	100 ± 10	103 ± 3	113 ± 10
Caspase 12 (Casp12)	100 ± 7	122 ± 3^*	120 ± 16
HCLS1 associated protein X-1 (Hax1)	100 ± 5	91 ± 3	106 ± 12
Fatty acid binding protein 3 (Fabp3)	100 ± 7	70 ± 4^*	75 ± 7^*
Carnitine palmitoyltransferase 1 (Cpt1b)	100 ± 2	77 ± 3^*	70 ± 8^*
Glucose transporter 4 (Slc2a4)	100 ± 12	88 ± 2	95 ± 8

Heart RNA from wild-type (WT) mice, transgenic mice expressing Glu154Lys mutant α-tropomyosin (DCM), and DCM/Atp2a2^+/− double mutant (DCM/HET) mice was analyzed by RT-PCR. Values are mean ± SE; = at least 4 for each genotype; ^* < 0.05 versus WT controls.