Use of Early Biomarkers in Neonatal Brain Damage and Sepsis: State of the Art and Future Perspectives

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left">Biomarkers of brain injury</td><td align="center">Reference curves in neonates</td><td align="center">Assay</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">S100B</td><td align="center">Y</td><td align="center">Chemiluminescence/ELISA</td></tr><tr><td align="left">AM</td><td align="center">NA</td><td align="center">ELISA</td></tr><tr><td align="left">EPO</td><td align="center">Incomplete</td><td align="center">Chemiluminescence/ELISA</td></tr><tr><td align="left">Activin A</td><td align="center">Incomplete</td><td align="center">ELISA</td></tr><tr><td align="left">NSE</td><td align="center">NA</td><td align="center">ELISA</td></tr><tr><td align="left">OS</td><td align="center">Incomplete</td><td align="center">ELISA/HPLC</td></tr><tr><td align="left">G-FAP</td><td align="center">NA</td><td align="center">ELISA</td></tr><tr><td align="left">CK-BB</td><td align="center">Incomplete</td><td align="center">Electrophoresis</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>AM: adrenomedullin; EPO: erythropoietin; NSE: neuron-specific enolase; OS: oxidative stress markers; G-FAP: glial fibrillary acidic protein; CK-BB: creatine kinase BB; Y: yes; NA: not available.<br/></td></tr></table>

Biomarkers of brain injury in the neonatal period: reference curves availability and assays.

BioMed Research International

tab1

Table 1

Table 1: Use of Early Biomarkers in Neonatal Brain Damage and Sepsis: State of the Art and Future Perspectives 