Research Article

Viability, Apoptosis, Proliferation, Activation, and Cytokine Secretion of Human Keratoconus Keratocytes after Cross-Linking

Table 2

Concentration (pg/μg protein) of different cytokines in keratoconus keratocyte cultures twenty-four hours after treatment.

KeratocytesKeratocytes + riboflavinKeratocytes + 370 nmKeratocytes + riboflavin + 370 nm value value value

FGFb1.1 ± 0.362.26 ± 1.31.09 ± 0.362.88 ± 2.530.120.750.3
HGF3.94 ± 0.84.39 ± 0.773.72 ± 0.264.28 ± 0.710.350.350.6
TGFβ14.66 ± 0.14.62 ± 0.464.62 ± 0.44.43 ± 0.440.60.920.12
VEGF12.75 ± 2.0116.02 ± 4.8211.7 ± 2.4714.92 ± 3.80.180.350.25
KGFn.d.n.d.n.d.n.d.n/a n/a n/a
IL-1βn.d.n.d.n.d.n.d.n/a n/a n/a
IL-60.31 ± 0.160.45 ± 0.260.29 ± 0.170.37 ± 0.150.530.60.75
IL-88.95 ± 2.648.11 ± 2.419.43 ± 2.797.52 ± 1.590.470.920.35

Values indicate mean ± SD.
values indicate the difference between “keratocytes” versus “keratocytes + 370 nm” groups (Mann-Whitney test).
values indicate the difference between “keratocytes” versus “keratocytes + riboflavin” groups (Mann-Whitney test).
values indicate the difference between “keratocytes” versus “keratocytes + riboflavin + 370 nm” groups (Mann-Whitney test).
n.d. = not detectable.
n/a = not applicable.