Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts

Table 3

mRNAs altered by at least twofold after 4 h H₂O₂ exposure in villous 3A trophoblasts.

Gene symbol	Gene description	Fold change^b
HBEGF^a	Heparin-binding EGF-like growth factor	5.7637
ANGPT2	Angiopoietin 2	−2.4932
CCL2	Chemokine (C-C motif) ligand 2	−2.3834
CD40LG	CD40 ligand	−2.2084
CP	Ceruloplasmin (ferroxidase)	−2.2705
CRH	Corticotropin releasing hormone	−2.1038
DCN	Decorin	−2.0042
HP	Haptoglobin	−2.4083
IGF1	Insulin-like growth factor 1 (somatomedin C)	−2.5991
IL18	Interleukin 18 (interferon-gamma-inducing factor)	−2.6445
IL1A	Interleukin 1, alpha	−2.0748
IL6	Interleukin 6 (interferon, beta 2)	−2.0181
LEP	Leptin	−8.4152
LPL	Lipoprotein lipase	−2.2238
MMP9	Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase)	−2.0748
NDRG1	N-myc downstream regulated 1	−2.5901
NTRK2	Neurotrophic tyrosine kinase, receptor, type 2	−2.6721
PAPPA2	Pappalysin 2	−2.3102
QPCT	Glutaminyl-peptide cyclotransferase	−2.5368
SERPINA3	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	−2.1705
TAC1	Tachykinin, precursor 1	−2.5368
TNF	Tumor necrosis factor	−5.1266

 ^aUpregulated gene is in bold font.
^bFold change in H₂O₂ treated cells compared to nontreated control.