Investigation of Ser315 Substitutions within katG Gene in Isoniazid-Resistant Clinical Isolates of Mycobacterium tuberculosis from South India
Table 1
Mutational profile of INH-resistant clinical isolates of M. tuberculosis from south India.
Serial number
DST
katG
States
Serial number
DST
katG
States
1
MDR
ACC
TN
44
MDR
AAC
TN
2
MDR
ACC
TN
45
MDR
ACC
TN
3
MDR
ACC
TN
46
H
AAC
TN
4
H
TN
47
H
AAC
TN
5
H
TN
48
H
TN
6
H
TN
49
H
TN
7
H
ACC
TN
50
H
ACC
TN
8
MDR
TN
51
H
ACC
TN
9
MDR
ACC
TN
52
H
ACC
TN
10
MDR
ATC
TN
53
MDR
ATC
TN
11
MDR
ACC
TN
54
MDR
ACC
TN
12
MDR
ACC
TN
55
H
CGC
TN
13
H
TN
56
MDR
TN
14
H
TN
57
MDR
ACC
TN
15
MDR
ACC
TN
58
H
TN
16
MDR
TN
59
MDR
TN
17
MDR
AAC
TN
60
MDR
ACC
TN
18
H
TN
61
H
ACC
TN
19
H
AAC
TN
62
H
ACC
TN
20
MDR
ACC
TN
63
H
TN
21
MDR
ACC
TN
64
MDR
ACC
TN
22
H
TN
65
MDR
ACC
TN
23
MDR
ACC
TN
66
MDR
ACC
TN
24
MDR
TN
67
MDR
ACC
TN
25
H
ACC
TN
68
MDR
ACC
AP
26
H
ACC
TN
69
H
AP
27
H
ACC
TN
70
H
ACC
AP
28
MDR
TN
71
MDR
AP
29
H
TN
72
MDR
AP
30
MDR
TN
73
MDR
ACC
AP
31
H
TN
74
MDR
AP
32
MDR
AAC
TN
75
MDR
AP
33
H
ACC
TN
76
MDR
ACC
AP
34
H
ACC
TN
77
MDR
AP
35
H
ACC
TN
78
MDR
ACC
AP
36
H
ACC
TN
79
MDR
ACC
AP
37
MDR
ACC
TN
80
H
ACC
AP
38
MDR
ACC
TN
81
H
ACC
AP
39
H
ACC
TN
82
H
KA
40
H
ACC
TN
83
H
KA
41
MDR
TN
84
H
ACC
KA
42
H
ACC
TN
85
H
ACC
K
43
MDR
ACC
TN
Strains with MIC of 1 mg/liter (number 1–28, 68–85), 5 mg/liter (number 29–45), and >5 mg/liter (number 46–67). Tamil Nadu cultures (number 1–67) and other states cultures (number 68–85). AP: Andhra Pradesh, KA: Karnataka, K: Kerala, H: isoniazid, and MDR: multidrug resistant.