Analysis of the Expression and Polymorphism of APOE, HSP, BDNF, and GRIN2B Genes Associated with the Neurodegeneration Process in the Pathogenesis of Primary Open Angle Glaucoma
Table 4
The genotype and allele frequency and odds ratios (OR) of the gene polymorphisms in open angle glaucoma (POAG) patients and controls.
Genotype or allele
POAG patients = 363
Control subjects = 406
OR (95% CI)
OR adjusted1 (95% CI)
HSP70-1
G/G
155 (43%)
179 (44%)
Ref
Ref
Ref
Ref
G/C
169 (47%)
170 (42%)
1.15 (0.85–1.55)
0.371
1.29 (0.94–1.77)
0.107
C/C
39 (10%)
57 (14%)
0.79 (0.50–1.25)
0.315
0.67 (0.42–1.08)
0.103
G
479 (66%)
528 (65%)
Ref
Ref
Ref
Ref
C
247 (34%)
284 (35%)
0.96 (0.78–1.18)
0.699
0.94 (0.76–1.17)
0.630
Post hoc power analysis: df = 2, = 769 Effect size = 0.132; power (1 − β err prob) = 0.919
BDNF
C/C
86 (24%)
146 (36%)
Ref
Ref
Ref
Ref
C/T
192 (53%)
190 (47%)
1.72 (1.23–2.39)
<0.001
1.43 (1.04–1.95)
0.024
T/T
85 (23%)
70 (17%)
2.06 (1.36–3.12)
<0.001
2.01 (1.92–2.23)
0.008
C
364 (50%)
482 (59%)
Ref
Ref
Ref
Ref
T
362 (50%)
330 (41%)
1.45 (1.19–1.78)
<0.001
1.45 (1.18–1.78)
<0.001
Post hoc power analysis: df = 2, = 769 Effect size = 0.262; power (1 − β err prob) = 0.999
GRIN2B
C/C
331 (91%)
360 (89%)
Ref
Ref
Ref
Ref
C/A
31 (8%)
46 (11%)
0.73 (0.45–1.18)
0.203
0.80 (0.47–1.35)
0.417
A/A
1 (1%)
0 (0%)
—
—
—
—
C
693 (95%)
766 (94%)
Ref
Ref
Ref
Ref
A
33 (5%)
46 (6%)
0.79 (0.50–1.25)
0.320
0.87 (0.52–1.43)
0.589
Post hoc power analysis: df = 2, = 769 Effect size = 0.096; power (1 − β err prob) = 0.660
APOE
A/A
205 (56%)
257 (63%)
Ref
Ref
Ref
Ref
A/T
127 (35%)
124 (31%)
1.28(0.94–1.75)
0.112
1.19 (0.85–1.65)
0.302
T/T
31 (9%)
25 (6%)
1.55 (0.89–2.72)
0.119
1.61 (0.88–2.93)
0.115
A
537 (74%)
638 (79%)
Ref
Ref
Ref
Ref
T
189 (26%)
174 (21%)
1.29 (1.02–1.63)
0.034
1.35 (1.05–1.73)
0.018
Post hoc power analysis: df = 2, = 769 Effect size = 0.167; power (1 − β err prob) = 0.990
Odds ratio adjusted for hypertension, low blood pressure, vascular disease, and diabetes.
