Differentiation between Acute Skin Rejection in Allotransplantation and T-Cell Mediated Skin Inflammation Based on Gene Expression Analysis

Figure 4

Separation of the samples within the two combined studied groups by linear discrimination analysis (LDA). (a) Coefficients of the discriminant vector from a multivariate model indicating the contribution to the separation for each of the 17 studied genes, (b) separation of the two groups by values of the canonical variable for each sample resulting from LDA including all 17 cytokines/chemokines relative mRNA levels () and corresponding density distribution, (c) list of significant LDA models when studying all pairwise gene models, and (d) linear separation based on the levels of Ccl7 and Il1b are shown. Allografts skin samples are shown in gray, inflammatory skin disease is shown in black, and dashed gray line indicates linear separation and partition.