Administration of 4-(α-L-Rhamnosyloxy)-benzyl Isothiocyanate Delays Disease Phenotype in SOD1^G93A Rats: A Transgenic Model of Amyotrophic Lateral Sclerosis

Figure 7

Western blot analysis of FoxP3 and TNF-α expression and serum parameters. Brain protein extracts reveal significant differences. GMG-ITC treated SOD1tg rats present levels of FoxP3 higher than untreated animals (a) and TNF-alpha expression in spleen homogenates shows significant higher level of this marker in untreated than GMG-ITC treated SOD1tg rats (b). ; . PGE2 serum levels are significantly higher in untreated SOD1tg rats when compared with serum levels of animals treated with GMG-ITC (c). . About serum parameters, no electrolyte imbalance was measured in both groups looking at NA+/K+ levels, when creatine kinase (CK) enzyme was assayed, while a significant and interesting change was found comparing the CK levels of untreated SOD1tg rats higher than GMG-ITC treated animals (d). .

(a)

(b)

(c)

(d)