Ethnic-Specific Genetic Association of Variants in the Corticotropin-Releasing Hormone Receptor 1 Gene with Nicotine Dependence

Table 4

and permutated values for association of major CRHR1 haplotypes formed by SNPs rs171440, rs1396862, and rs878886 with three ND measures in the pooled AA and EA samples and SNPs rs171440 and rs1396862 in the AA sample.

Sample	SNPs	Haplotype	Frequency (%)	SQ	HSI	FTND
AA	rs171440 and rs1396862	C-C	56.9	−2.152^d; (0.031)	−1.416; (0.157)	−1.047; (0.295)
		T-C	38.9	2.155^r; (0.031)	1.619; (0.105)	1.467; (0.142)
Pooled samples	rs171440, rs1396862, and rs878886	C-C-G	47.6	−2.06; (0.039)	−1.334; (0.182)	−1.201; (0.230)
		T-C-G	42.3	2.232^r; (0.026)	1.840; (0.066)	2.008^r; (0.045)
		C-T-C	8.2	−0.315; (0.753)	−0.496; (0.620)	−1.195; (0.232)

Superscripts indicate the genetic models used for analysis; d: dominant; r: recessive model. Except for the model indicted, all other values shown in the Tables 3 and 4 were calculated under the additive model.