Obesity and Cancer Progression: Is There a Role of Fatty Acid Metabolism?

Figure 1

Intracellular fatty acid metabolism. A simplified cartoon of fatty acid metabolism pathways. Fatty acids are transported in the circulation as triacylglycerol (TAG) in lipoproteins and hydrolyzed by lipoprotein lipase (LPL) or they are bound to albumin and are transported across the plasma membrane. A CoA is ligated to fatty acid (FA), and the fatty acyl-CoA (FA-CoA) can enter the glycerolipid synthesis pathway for storage or the mitochondria for oxidation. ACS, acyl-CoA synthase; AGPAT, acyl-CoA: acylglycerol-3-phosphate acyltransferase; ATGL, adipose triglyceride lipase; DAG, diacylglycerol; DGAT, diacylglycerol acyltransferase; GPAT, glycerol-3-phosphate acyltransferase; HSL, hormone-sensitive lipase; LPA, lysophosphatidic acid; MAG, monoacylglycerol; MAGL, monoacylglycerol lipase; PA, phosphatidic acid.