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BioMed Research International
Volume 2015 (2015), Article ID 275062, 13 pages
Research Article

Creating Well-Being: Increased Creativity and proNGF Decrease following Quadrato Motor Training

1Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, 00185 Rome, Italy
2Institute of Biology and Molecular Pathology, National Research Council (CNR), 00185 Rome, Italy
3Department of Movement, Human and Health Sciences, Italian University for Sport and Movement, Rome, Italy
4Research Institute for Neuroscience, Education and Didactics, Patrizio Paoletti Foundation, Via Cristoforo Cecci 2, Santa Maria degli Angeli, 06081 Assisi, Italy

Received 18 August 2014; Accepted 16 November 2014

Academic Editor: Patricia Gerbarg

Copyright © 2015 Sabrina Venditti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mind-body practices (MBP) are known to induce electrophysiological and morphological changes, whereas reports related to changes of neurotrophins are surprisingly scarce. Consequently, in the current paper, we focused on the Quadrato motor training (QMT), a newly developed whole-body movement-based MBP, which has been reported to enhance creativity. Here we report the effects of 4 weeks of daily QMT on creativity and proNGF level in two interrelated studies. In Study A, we examined the effects of QMT compared with a walking training (WT) in healthy adults, utilizing the alternate uses task. In contrast with the WT, QMT resulted in increased creativity. In addition, the change in creativity negatively correlated with the change in proNGF levels. In Study B, we examined QMT effects on creativity and additional metacognitive functions in children, using a nonintervention group as control. Similar to Study A, following QMT, we found a negative correlation of proNGF with creativity, as well as working memory updating and planning ability. Together, the current results point to the relationship between increased creativity and decreased proNGF following MBP. Thus, the current research emphasizes the importance of widening the scope of examination of “MBP in motion” in relation to metacognition and well-being.