Quantitative Assessment of the Association between Genetic Variants in MicroRNAs and Colorectal Cancer Risk

Table 2

MiRNA polymorphisms genotype distribution and allele frequency in cases and controls.

First author	Genotype ()								Allele frequency ()
	Case				Control				Case		Control		MAF	HWE ( value)
	Total	AA	Aa	aa	Total	AA	Aa	aa	A	a	A	a
rs2910164
Dikaiakos 2015 [28]	157	8	48	101	299	21	120	158	64	250	162	436	0.80	0.782
Kupcinskas 2014 [29]	193	140	50	2	428	275	134	15	330	54	684	164	0.14	0.789
Mao 2014 [30]	554	70	291	186	566	85	271	205	431	663	441	681	0.61	0.768
Hu 2014 [31]	200	34	82	84	373	44	187	142	250	150	275	471	0.38	0.137
Wu 2014 [15]	175	22	59	80	300	53	120	114	103	219	226	348	0.68	0.035
Lv 2013 [8]	331	54	230	47	513	96	274	143	338	324	560	466	0.49	0.080
Chae 2013 [21]	399	61	182	156	568	121	282	165	304	494	524	612	0.62	0.980
Ma 2013 [36]	1147	444	534	169	1203	397	614	192	1422	872	1408	998	0.38	0.075
Vinci 2013 [16]	160	17	57	86	178	13	65	100	91	229	91	265	0.72	0.590
Hezova 2012 [20]	197	115	70	12	212	124	79	9	300	94	327	97	0.24	0.415
Min 2012 [22]	446	151	233	62	502	188	245	69	535	357	621	383	0.40	0.443
rs2292832
Wu 2014 [15]	175	21	123	28	300	76	58	116	165	179	210	290	0.52	<0.001
Lv 2013 [8]	347	30	64	253	459	48	103	308	124	570	199	719	0.82	<0.001
Vinci 2013 [16]	160	79	58	23	178	86	75	17	216	104	247	109	0.33	0.912
Zhang 2012 [14]	443	50	190	203	435	46	202	187	290	596	294	576	0.67	0.431
Min 2012 [22]	446	48	177	221	502	51	219	232	273	619	321	683	0.69	0.948
rs11614913
Dikaiakos 2015 [28]	157	19	69	69	299	33	149	117	107	207	215	383	0.66	0.156
Kupcinskas 2014 [29]	193	79	87	27	428	199	174	54	245	141	572	282	0.37	0.104
Lv 2013 [8]	374	10	223	114	531	109	331	91	243	451	549	413	0.60	<0.001
Vinci 2013 [16]	160	62	86	12	178	83	84	11	210	110	250	106	0.34	0.087
Hezova 2012 [20]	197	82	89	26	212	87	103	22	253	141	277	147	0.36	0.291
Zhang 2012 [14]	455	79	204	172	463	81	197	185	362	548	359	567	0.60	0.026
Min 2012 [22]	466	120	201	125	502	100	254	148	441	451	454	550	0.48	0.633
Zhu 2012 [33]	573	140	303	130	588	121	295	172	583	563	537	639	0.49	0.790
Chen 2012 [34]	126	27	64	35	407	94	206	107	118	134	394	420	0.53	0.788
Zhan 2011 [35]	252	68	128	56	543	112	267	163	264	240	493	593	0.48	0.890
rs3746444
Dikaiakos 2015 [28]	157	85	64	8	299	182	99	18	234	80	463	135	0.25	0.361
Hu 2014 [31]	211	157	49	5	373	282	81	10	363	59	654	101	0.14	0.162
Wu 2014 [15]	175	96	17	38	300	141	44	63	209	93	326	170	0.31	<0.001
Lv 2013 [8]	346	258	88		504	366	138						—	—
Vinci 2013 [16]	160	35	32	93	178	17	56	105	102	218	90	266	0.68	0.026
Min 2012 [22]	446	292	142	12	502	334	154	14	726	166	822	182	0.19	0.453

A: the major allele; a: the minor allele; MAF: minor allele frequencies.