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BioMed Research International
Volume 2015 (2015), Article ID 278931, 10 pages
http://dx.doi.org/10.1155/2015/278931
Research Article

Cinnabar-Induced Subchronic Renal Injury Is Associated with Increased Apoptosis in Rats

Department of Occupational and Environmental Health, School of Public Health, Liaoning Medical University, Jinzhou, Liaoning 121001, China

Received 4 June 2014; Accepted 26 September 2014

Academic Editor: Rita Rezzani

Copyright © 2015 Ying Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Chinese Pharmacopoeia, People’s Press, Beijing, China, 2010.
  2. A. Kumar, A. G. C. Nair, A. V. R. Reddy, and A. N. Garg, “Bhasmas: unique Ayurvedic metallic-herbal preparations, chemical characterization,” Biological Trace Element Research, vol. 109, no. 3, pp. 231–254, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. S. U. Kamath, B. Pemiah, R. K. Sekar, S. Krishnaswamy, S. Sethuraman, and U. M. Krishnan, “Mercury-based traditional herbo-metallic preparations: a toxicological perspective,” Archives of Toxicology, vol. 86, no. 6, pp. 831–838, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. J. F. Wang, “Angong Niuhuang Wan treat 30 cases of large area cerebral infarction combined with hyperthermia,” Shanxi Zhong Yi, vol. 32, no. 3, pp. 290–291, 2011. View at Google Scholar
  5. H. J. Zhang and X. L. Dong, “Effect of Angong Niuhuang Wan in the treatment of viral encephalitis in children,” Zhongguo Zhong Xi Yi Jie He Er Ke Xue, vol. 6, no. 4, pp. 326–328, 2014. View at Google Scholar
  6. P. S. Yang, “Clinical observation of the effect of Zhusha Anshen Wan and zhennaoning capsule combination on 43 cases intractable insomnia,” Zhongguo She Qu Yi Shi, vol. 11, no. 16, pp. 130–131, 2009. View at Google Scholar
  7. Y.-F. Lu, Q. Wu, J.-W. Yan, J.-Z. Shi, J. Liu, and J.-S. Shi, “Realgar, cinnabar and An-Gong-Niu-Huang Wan are much less chronically nephrotoxic than common arsenicals and mercurials,” Experimental Biology and Medicine, vol. 236, no. 2, pp. 233–239, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. Y. F. Lu, J. W. Yan, Q. Wu, J. Z. Shi, J. Liu, and J. S. Shi, “Realgar- and cinnabar-containing An-Gong-Niu-Huang Wan (AGNH) is much less acutely toxic than sodium arsenite and mercuric chloride,” Chemico-Biological Interactions, vol. 189, no. 1-2, pp. 134–140, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. J.-Z. Shi, F. Kang, Q. Wu, Y.-F. Lu, J. Liu, and Y. J. Kang, “Nephrotoxicity of mercuric chloride, methylmercury and cinnabar-containing Zhu-Sha-An-Shen-Wan in rats,” Toxicology Letters, vol. 200, no. 3, pp. 194–200, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. A.-H. Liang, Y.-J. Xu, and M.-F. Shang, “Analysis of adverse effects of cinnabar,” Zhongguo Zhongyao Zazhi, vol. 30, no. 23, pp. 1809–1811, 2005. View at Google Scholar · View at Scopus
  11. A.-H. Liang and M.-F. Shang, “General situation of the study on the toxicity of Cinnabaris,” China Journal of Chinese Materia Medica, vol. 30, no. 4, pp. 249–252, 2005. View at Google Scholar · View at Scopus
  12. X. Zhou, K. Zeng, Q. Wang, X. Yang, and K. Wang, “In vitro studies on dissolved substance of cinnabar: chemical species and biological properties,” Journal of Ethnopharmacology, vol. 131, no. 1, pp. 196–202, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. R. K. Zalups, “Molecular interactions with mercury in the kidney,” Pharmacological Reviews, vol. 52, no. 1, pp. 113–143, 2000. View at Google Scholar · View at Scopus
  14. C.-F. Huang, S.-H. Liu, and S.-Y. Lin-Shiau, “Neurotoxicological effects of cinnabar (a Chinese mineral medicine, HgS) in mice,” Toxicology and Applied Pharmacology, vol. 224, no. 2, pp. 192–201, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. C.-C. Yen, S.-H. Liu, W.-K. Chen, R.-H. Lin, and S.-Y. Lin-Shiau, “Tissue distribution of different mercurial compounds analyzed by the improved FI-CVAAS,” Journal of Analytical Toxicology, vol. 26, no. 5, pp. 286–295, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. T. S. Yeoh, A. S. Lee, and H. S. Lee, “Absorption of mercuric sulphide following oral administration in mice,” Toxicology, vol. 41, no. 1, pp. 107–111, 1986. View at Publisher · View at Google Scholar · View at Scopus
  17. A.-M. M. Fouda, M.-H. Y. Daba, G. M. Dahab, and O. A. Sharaf El-Din, “Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats,” Basic and Clinical Pharmacology and Toxicology, vol. 103, no. 2, pp. 109–118, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. K. A. Nath, A. J. Croatt, S. Likely, T. W. Behrens, and D. Warden, “Renal oxidant injury and oxidant response induced by mercury,” Kidney International, vol. 50, no. 3, pp. 1032–1043, 1996. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Carranza-Rosales, S. Said-Fernández, J. Sepúlveda-Saavedra, D. E. Cruz-Vega, and A. J. Gandolfi, “Morphologic and functional alterations induced by low doses of mercuric chloride in the kidney OK cell line: ultrastructural evidence for an apoptotic mechanism of damage,” Toxicology, vol. 210, no. 2-3, pp. 111–121, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. J. S. Woods, F. J. Dieguez-Acuña, M. E. Ellis, J. Kushleika, and P. L. Simmonds, “Attenuation of nuclear factor kappa B (NF-κB) promotes apoptosis of kidney epithelial cells: a potential mechanism of mercury-induced nephrotoxicity,” Environmental Health Perspectives, vol. 110, no. supplement 5, pp. 819–822, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Wei, P. Liao, H. Wu et al., “Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum,” Toxicology and Applied Pharmacology, vol. 227, no. 3, pp. 417–429, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. C. K. Peng, X. R. Zhou, J. Fu, Z. M. Ren, L. Q. Shang, and X. T. Wei, “Comparison of the neurotoxicity and nephrotoxicity induced by cinnabar, mercuric chloride and mercuric sulfide,” Xian Dai Yu Fang Yi Xue, vol. 38, no. 24, pp. 5099–5102, 2011. View at Google Scholar
  23. A. Lianag, J. Wang, B. Xue et al., “Study on hepatoxicity and nephrotoxicity of cinnabar in rats,” Zhongguo Zhong Yao Za Zhi, vol. 34, no. 3, pp. 312–318, 2009. View at Google Scholar · View at Scopus
  24. Q. Wu, Y.-F. Lu, J.-Z. Shi, S.-X. Liang, J. Liu, and J.-S. Shi, “Chemical form of metals in traditional medicines underlines potential toxicity in cell cultures,” Journal of Ethnopharmacology, vol. 134, no. 3, pp. 839–843, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. R.-J. Huang, Z.-X. Zhuang, Y.-R. Wang, Z.-Y. Huang, X.-R. Wang, and F. S. C. Lee, “An analytical study of bioaccumulation and the binding forms of mercury in rat body using thermolysis coupled with atomic absorption spectrometry,” Analytica Chimica Acta, vol. 538, no. 1-2, pp. 313–321, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. J.-D. Park and W. Zheng, “Human exposure and health effects of inorganic and elemental mercury,” Journal of Preventive Medicine and Public Health, vol. 45, no. 6, pp. 344–352, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. Y. Zhou, V. S. Vaidya, R. P. Brown et al., “Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium,” Toxicological Sciences, vol. 101, no. 1, pp. 159–170, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. X.-L. Liu, H.-B. Wang, C.-W. Sun et al., “The clinical analysis of mercury poisoning in 92 cases,” Chinese Journal of Internal Medicine, vol. 50, no. 8, pp. 687–689, 2011. View at Google Scholar · View at Scopus
  29. H. Wang, J. Bai, G. Chen et al., “A metabolic profiling analysis of the acute hepatotoxicity and nephrotoxicity of Zhusha Anshen Wan compared with cinnabar in rats using 1H NMR spectroscopy,” Journal of Ethnopharmacology, vol. 146, no. 2, pp. 572–580, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. A. L. Edinger and C. B. Thompson, “Death by design: apoptosis, necrosis and autophagy,” Current Opinion in Cell Biology, vol. 16, no. 6, pp. 663–669, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. M. D. Jacobson, M. Weil, and M. C. Raff, “Programmed cell death in animal development,” Cell, vol. 88, no. 3, pp. 347–354, 1997. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Eichler, Q. Ma, C. Kelly et al., “Single and combination toxic metal exposures induce apoptosis in cultured murine podocytes exclusively via the extrinsic caspase 8 pathway,” Toxicological Sciences, vol. 90, no. 2, pp. 392–399, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. C.-M. Liu, J.-Q. Ma, and Y.-Z. Sun, “Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway,” Toxicology and Applied Pharmacology, vol. 258, no. 3, pp. 330–342, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. S. V. S. Rana, “Metals and apoptosis: recent developments,” Journal of Trace Elements in Medicine and Biology, vol. 22, no. 4, pp. 262–284, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. T. Allard, T. Wenner, H. J. Greten, and T. Efferth, “Mechanisms of herb-induced nephrotoxicity,” Current Medicinal Chemistry, vol. 20, no. 22, pp. 2812–2819, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. Z. Xiao, J. Shan, C. Li et al., “Mechanisms of cyclosporine-induced renal cell apoptosis: a systematic review,” The American Journal of Nephrology, vol. 37, no. 1, pp. 30–40, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. B. Fadeel, S. Orrenius, and B. Zhivotovsky, “Apoptosis in human disease: a new skin for the old ceremony?” Biochemical and Biophysical Research Communications, vol. 266, no. 3, pp. 699–717, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. N. Ueda, R. Baliga, and S. V. Shah, “Role of “catalytic” iron in an animal model of minimal change nephrotic syndrome,” Kidney International, vol. 49, no. 2, pp. 370–373, 1996. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. Fujiwara, J.-Y. Lee, M. Tokumoto, and M. Satoh, “Cadmium renal toxicity via apoptotic pathways,” Biological and Pharmaceutical Bulletin, vol. 35, no. 11, pp. 1892–1897, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. J. Zhang, H. Cao, Y. Zhang et al., “Nephroprotective effect of calcium channel blockers against toxicity of lead exposure in mice,” Toxicology Letters, vol. 218, no. 3, pp. 273–280, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. S. Kumar, “Mechanisms mediating caspase activation in cell death,” Cell Death and Differentiation, vol. 6, no. 11, pp. 1060–1066, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. A. Ortiz, “Apoptotic regulatory proteins in renal injury,” Kidney International, vol. 58, no. 1, pp. 467–485, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  43. C. Lorz, A. Ortiz, P. Justo et al., “Proapoptotic Fas ligand is expressed by normal kidney tubular epithelium and injured glomeruli,” Journal of the American Society of Nephrology, vol. 11, no. 7, pp. 1266–1277, 2000. View at Google Scholar · View at Scopus
  44. J. G. Boonstra, F. J. van der Woude, P. C. Wever, J. C. Laterveer, M. R. Daha, and C. van Kooten, “Expression and function of Fas (CD95) on human renal tubular epithelial cells,” Journal of the American Society of Nephrology, vol. 8, no. 10, pp. 1517–1524, 1997. View at Google Scholar · View at Scopus
  45. C. Lorz, A. Benito-Martin, A. Boucherot et al., “The death ligand TRAIL in diabetic nephropathy,” Journal of the American Society of Nephrology, vol. 19, no. 5, pp. 904–914, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  46. M. D. Sanchez-Niño, A. B. Sanz, P. Ihalmo et al., “The MIF receptor CD74 in diabetic podocyte injury,” Journal of the American Society of Nephrology, vol. 20, no. 2, pp. 353–362, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  47. S.-J. Zheng, P. Wang, G. Tsabary, and Y. H. Chen, “Critical roles of TRAIL in hepatic cell death and hepatic inflammation,” Journal of Clinical Investigation, vol. 113, no. 1, pp. 58–64, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. A. Maeshima, Y. Nojima, and I. Kojima, “Activin A: an autocrine regulator of cell growth and differentiation in renal proximal tubular cells,” Kidney International, vol. 62, no. 2, pp. 446–454, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  49. Y. Sun and X. Chen, “Effect of adiponectin on apoptosis: proapoptosis or antiapoptosis?” BioFactors, vol. 36, no. 3, pp. 179–186, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  50. X. Jin, J. Chen, Z. Hu, L. Chan, and Y. Wang, “Genetic deficiency of adiponectin protects against acute kidney injury,” Kidney International, vol. 83, no. 4, pp. 604–614, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus