Experimentally Induced Mammalian Models of Glaucoma

Table 2

Experimentally induced in vitro and ex vivo mammalian glaucoma models.

	Species	Main papers	Pressure (mm Hg)	Duration (hours)	Main outcomes measured
In vitro glaucoma models
Hydro pressure model	Porcine	Obazawa et al. (2004) [73]	3, 33	12, 24, 48, 72	Optineurin and myocilin expression in trabecular meshwork cells
Centrifugation model	Rat	Kashiwagi et al. (2004) [74]	16, 28, 33	24, 48	Expressional changes in mRNA in RGC and retinal glia
Ex vivo glaucoma models
Hydro pressure model	Rat	Ishikawa et al. (2010) [17]	10, 25, 50, 75	24	Histology of the retinal nerve fiber, Glutamine synthetase activity
Gas pressure model	Bovine	Reigada et al. (2008) [91]	20–100	0.5	Retinal ATP release