BioMed Research International / 2015 / Article / Tab 2

Review Article

Experimentally Induced Mammalian Models of Glaucoma

Table 2

Experimentally induced in vitro and ex vivo mammalian glaucoma models.

Species Main papers Pressure (mm Hg)Duration (hours)Main outcomes measured

In vitro glaucoma models
 Hydro pressure model Porcine Obazawa et al. (2004) [73] 3, 33 12, 24, 48, 72 Optineurin and myocilin expression in trabecular meshwork cells
 Centrifugation model Rat Kashiwagi et al. (2004) [74] 16, 28, 33 24, 48 Expressional changes in mRNA in RGC and retinal glia

Ex vivo glaucoma models
 Hydro pressure model Rat Ishikawa et al. (2010) [17] 10, 25, 50, 75 24 Histology of the retinal nerve fiber, Glutamine synthetase activity
 Gas pressure model Bovine Reigada et al. (2008) [91] 20–100 0.5 Retinal ATP release

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