The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese
Table 3
Estimated joint effects on models of 2- to 5-SNP combinations associated with breast cancer.
Combined SNP number (specific SNP combination)*1
SNP genotypes
Case number /control number
OR
95% CI
value
Power
2-SNP
Others
330/261
1
0.005*2
0.792
(1-2)
1-1
15/29
0.409
0.215–0.779
3-SNP
Others
330/261
1
0.005*2
0.792
(1-2-5)
1-1-2
15/29
0.409
0.215–0.779
4-SNP
Others
330/261
1
0.005*2
0.792
(1-2-3-5)
1-1-2-2
15/29
0.409
0.215–0.779
5-SNP
Others
330/262
1
0.008*2
0.750
(1-2-3-4-5)
1-1-2-1-2
15/28
0.425
0.223–0.813
The information of the SNP and genotypes is provided in Table 1. *2The models have significance on the occurrence of breast cancer (P < 0.05). OR = odds ratio.