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BioMed Research International
Volume 2015, Article ID 284154, 9 pages
http://dx.doi.org/10.1155/2015/284154
Clinical Study

Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study

1Trupti Hospital and Santati Fertility Center, Cosmos Paradise, Pokhran Road 1, Link Road, Thane, Maharashtra 400 606, India
2Department of Pharmacology, BVDU Dental College & Hospital, Sector 7, C.B.D., Belpada, Navi Mumbai, Maharashtra 400 614, India
3Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. Saha Road, Kolkata 700053, India

Received 22 June 2015; Revised 27 August 2015; Accepted 8 September 2015

Academic Editor: Seiichi Saito

Copyright © 2015 Swati Dongre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. S. Kaplan, “The new sex therapy. Active treatment of sexual dysfunctions (book),” The Journal of Sex Research, vol. 11, 1974. View at Google Scholar
  2. J. R. Berman, L. A. Berman, T. J. Werbin, and I. Goldstein, “Female sexual dysfunction: anatomy, physiology, evaluation and treatment options,” Current Opinion in Urology, vol. 9, no. 6, pp. 563–568, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. M. A. Perelman, “Clinical application of CNS-Acting agents in FSD,” Journal of Sexual Medicine, vol. 4, no. 4, pp. 280–290, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Chandrasekhar, J. Kapoor, and S. Anishetty, “A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults,” Indian Journal of Psychological Medicine, vol. 34, no. 3, pp. 255–262, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Archana and A. Namasivayam, “Antistressor effect of Withania somnifera,” Journal of Ethnopharmacology, vol. 64, no. 1, pp. 91–93, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Öberg and K. S. Fugl-Meyer, “On Swedish women's distressing sexual dysfunctions: some concomitant conditions and life satisfaction,” Journal of Sexual Medicine, vol. 2, no. 2, pp. 169–180, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Singh, R. (Mrs.) Nath, A. (Miss) Lata, S. P. Singh, R. P. Kohli, and K. P. Bhargava, “Withania somnifera (Ashwagandha), a rejuvenating herbal drug which enhances survival during stress (an Adaptogen),” Pharmaceutical Biology, vol. 20, no. 1, pp. 29–35, 1982. View at Publisher · View at Google Scholar · View at Scopus
  8. A. A. Mahdi, K. K. Shukla, M. K. Ahmad et al., “Withania somnifera improves semen quality in stress-related male fertility,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 576962, 9 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. V. R. Ambiye, D. Langade, S. Dongre, P. Aptikar, M. Kulkarni, and A. Dongre, “Clinical evaluation of the spermatogenic activity of the root extract of Ashwagandha (Withania somnifera) in oligospermic males: a pilot study,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 571420, 6 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. D. A. Kalmbach, S. A. Kingsberg, and J. A. Ciesla, “How changes in depression and anxiety symptoms correspond to variations in female sexual response in a nonclinical sample of young women: a daily diary study,” Journal of Sexual Medicine, vol. 11, no. 12, pp. 2915–2927, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. B. A. Prairie, S. R. Wisniewski, J. Luther et al., “Symptoms of depressed mood, disturbed sleep, and sexual problems in midlife women: cross-sectional data from the study of women's health across the nation,” Journal of Women's Health, vol. 24, no. 2, pp. 119–126, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. D. J. Cosgrove, Z. Gordon, J. E. Bernie et al., “Sexual dysfunction in combat veterans with post-traumatic stress disorder,” Urology, vol. 60, no. 5, pp. 881–884, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. B. Auddy, J. Hazra, A. Mitra, B. Abedon, S. Ghosal, and S. L. City, “A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans,” Journal of the American Nutraceutical Association, vol. 11, pp. 51–57, 2008. View at Google Scholar
  14. K. Cooley, O. Szczurko, D. Perri et al., “Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974,” PLoS ONE, vol. 4, no. 8, Article ID e6628, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. L. M. Demers, “Androgen deficiency in women; role of accurate testosterone measurements,” Maturitas, vol. 67, no. 1, pp. 39–45, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Rosen, C. Brown, J. Heiman et al., “The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function,” Journal of Sex and Marital Therapy, vol. 26, no. 2, pp. 191–208, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. L. R. Derogatis, R. Rosen, S. Leiblum, A. Burnett, and J. Heiman, “The Female Sexual Distress Scale (FSDS): initial validation of a standardized scale for assessment of sexually related personal distress in women,” Journal of Sex & Marital Therapy, vol. 28, no. 4, pp. 317–330, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. C. H. Mercer, “Sexual behaviour,” Medicine, vol. 42, no. 6, pp. 291–293, 2014. View at Publisher · View at Google Scholar
  19. M. H. Mirjalili, E. Moyano, M. Bonfill, R. M. Cusido, and J. Palazón, “Steroidal lactones from Withania somnifera, an ancient plant for novel medicine,” Molecules, vol. 14, no. 7, pp. 2373–2393, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. K.-J. Oh, M.-J. Chae, H.-S. Lee, H.-D. Hong, and K. Park, “Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study,” Journal of Sexual Medicine, vol. 7, no. 4, pp. 1469–1477, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Aslan, N. K. Beji, I. Gungor, A. Kadioglu, and B. K. Dikencik, “Re: Prevalence and risk factors for low sexual function in women: a study of 1,009 women in an outpatient clinic of a university hospital in istanbul-a response,” Journal of Sexual Medicine, vol. 6, no. 5, pp. 1491–1492, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. R. E. Nappi, F. Albani, P. Vaccaro et al., “Use of the Italian translation of the Female Sexual Function Index (FSFI) in routine gynecological practice,” Gynecological Endocrinology, vol. 24, no. 4, pp. 214–219, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. C. M. Meston, A. H. Rellini, and M. J. Telch, “Short- and long-term effects of Ginkgo biloba extract on sexual dysfunction in women,” Archives of Sexual Behavior, vol. 37, no. 4, pp. 530–547, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Basson and L. A. Brotto, “Sexual psychophysiology and effects of sildenafil citrate in oestrogenised women with acquired genital arousal disorder and impaired orgasm: a randomised controlled trial,” BJOG, vol. 110, no. 11, pp. 1014–1024, 2003. View at Publisher · View at Google Scholar · View at Scopus