Table 3: Distribution of Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 polymorphisms in Mexican-Mestizo population.

Study groupGenotype (%)Phenotype (%)Allele (%)
PPARGC1A Gly482Ser
rs8192678
Gly/Gly (Ser−)Gly/SerSer/Ser (Gly−)Gly+Ser+GlySer

Normal range77 (50)60 (39)16 (11)137 (89)76 (50)214 (70)92 (30)
Preobese74 (51)54 (38)16 (11)128 (89)70 (49)202 (70)86 (30)
Obese38 (49)31 (40)9 (11)69 (89)40 (51)107 (70)49 (30)
1NS 2NS 2NS 5NS
Without obesity151 (51)114 (38)32 (11)265 (89)146 (49)416 (70)178 (30)
3NS 4NS 4NS 6NS

PPARG2 Pro12Ala
rs1801282
Pro/Pro (Ala−)Pro/AlaAla/Ala (Pro−)Pro+Ala+ProAla

Normal range117 (76)34 (23)2 (1)151 (99)36 (24)268 (87)38 (13)
Preobese117 (81)27 (19)0 (0)144 (100)27 (19)261 (90)27 (10)
Obese61 (78)13 (17)4 (5)74 (95)17 (22)135 (87)21 (13)
10.047 20.014 2NS 5NS
Without obesity234 (78)61 (21)2 (1)295 (99)63 (22)529 (89)65 (11)
30.017 40.019 4NS 6NS

; NS: not significant; categorical variables were analyzed using χ2 or Fisher exact test, accordingly. Comparisons: 1normal range (BMI 18.5–24.9 kg/m2), preobese (BMI 25–29.9 kg/m2), and obese (BMI ≥ 30 kg/m2) by genotype; 2normal range, preobese, and obese by phenotype; 3obese and without obesity (BMI: 18.5–29.9 kg/m2) by genotype; 4obese and without obesity by phenotype; 5normal range, preobese, and obese by allele; 6normal range and without obesity by allele.