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BioMed Research International
Volume 2015, Article ID 287048, 10 pages
Review Article

Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology

1Department of Human Genetics, National Health Institute Dr. Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisboa, Portugal
2Biosystems and Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisbon, 1749-016 Lisboa, Portugal

Received 20 October 2014; Accepted 16 December 2014

Academic Editor: Elena Orlova

Copyright © 2015 Vânia Gonçalves and Peter Jordan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Over the past decade, alternative splicing has been progressively recognized as a major mechanism regulating gene expression patterns in different tissues and disease states through the generation of multiple mRNAs from the same gene transcript. This process requires the joining of selected exons or usage of different pairs of splice sites and is regulated by gene-specific combinations of RNA-binding proteins. One archetypical splicing regulator is SRSF1, for which we review the molecular mechanisms and posttranscriptional modifications involved in its life cycle. These include alternative splicing of SRSF1 itself, regulatory protein phosphorylation events, and the role of nuclear versus cytoplasmic SRSF1 localization. In addition, we resume current knowledge on deregulated SRSF1 expression in tumors and describe SRSF1-regulated alternative transcripts with functional consequences for cancer cell biology at different stages of tumor development.