The HDAC Inhibitor Vorinostat Diminishes the In Vitro Metastatic Behavior of Osteosarcoma Cells

Figure 2

Morphological changes in the K7M2 actin cytoskeleton with increasing doses of vorinostat. Note expanded images of the control and vorinostat 100 μM cells. Vorinostat treatment caused the cells to become polygonal, become regular, and lose their invadopodia.