Long-Term Clinical Practice Experience with Cinacalcet for Treatment of Hypercalcemic Hyperparathyroidism after Kidney Transplantation

Table 2

Effect of cinacalcet on biochemical parameters of mineral metabolism in short- and long-term kidney transplant recipients.

	Total cohort	Short-term; (≤2 years)	Long-term; (>2 years)
		Kidney transplant recipients
		Total serum calcium, mmol/L	−0.30; (−0.34 to −0.26)	−0.33; (−0.38 to −0.27)	−0.26; (−0.32 to −0.21)
Fractional calcium excretion, %	0.24; (0.06 to 0.42)	0.28; (0.01 to 0.55)	0.19; (−0.06 to 0.44)
Serum inorganic phosphate, mmol/L	0.19; (0.15 to 0.23)	0.21; (0.14 to 0.27)	0.17; (0.13 to 0.21)
TmP/GFR, mmol/L	0.20; (0.16 to 0.23)	0.21; (0.15 to 0.26)	0.18; (0.13 to 0.23)
Intact parathyroid hormone, pg/mL	−66; (−91 to −41)	−84; (−128 to −40)	−45; (−64 to −26)

TmP/GFR, renal tubular reabsorption of phosphate to glomerular filtration rate; mean differences (95% confidence intervals) between pre- and posttreatment median values of biochemical parameters are presented for short-term (i.e., a median of 0.8 (0.5 to 0.9) years posttransplant) and long-term (i.e., a median of 4.8 (2.5 to 6.8) years posttransplant) kidney transplant recipients.