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BioMed Research International
Volume 2015 (2015), Article ID 292797, 7 pages
http://dx.doi.org/10.1155/2015/292797
Research Article

In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin

1Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105-700 Santa Maria, RS, Brazil
2Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri (URCA), 63100-000 Crato, CE, Brazil
3Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, 97105-700 Santa Maria, RS, Brazil
4Laboratório de Microbiologia e Biologia Molecular, Departamento de Química Biológica, Universidade Regional do Cariri, 63100-000 Crato,CE, Brazil
5Programa de Pós-Graduaçãoo em Farmacologia, Universidade Federal de Santa Maria, 97105-700 Santa Maria, RS, Brazil

Received 26 September 2014; Revised 12 February 2015; Accepted 15 February 2015

Academic Editor: Glen Jickling

Copyright © 2015 Dayanne Rakelly de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianum L. Gaertn.) clinically used as an antihepatotoxic agent. The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice. Silymarin demonstrated antimicrobial activity of little significance against the bacterial strains tested, with MIC (minimum inhibitory concentration) values of 512 µg/mL. Meanwhile, silibinin showed significant activity against Escherichia coli with a MIC of 64 µg/mL. The results for the antifungal activity of silymarin and silibinin demonstrated a MIC of 1024 µg/mL for all strains. Silymarin and silibinin appear to have promising potential, showing synergistic properties when combined with antibacterial drugs, which should prompt further studies along this line.