Research Article
The Power of Phase I Studies to Detect Clinical Relevant QTc Prolongation: A Resampling Simulation Study
Table 1
Scenarios used to investigate the influence of selection of time points.
| Designation | Maximum total number of time points | Number of time points in time window | 0 < t < 2 h | 2 h ≤ t ≤ 4 h | 4 h < t ≤ 8 h | 8 h < t ≤ 24 h |
| All | All | All | All | All | All | Equi 8 | 8 | At most 2 | At most 2 | At most 2 | At most 2 | Few | 7 | At most 2 | At most 1 | At most 2 | At most 2 | Exclude | 6 | At most 2 | None | At most 2 | At most 2 | Sparse | 4 | At most 1 | At most 1 | At most 1 | At most 1 |
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