Circulating MicroRNAs as Clinical Biomarkers in the Predictions of Pregnancy Complications

Table 1

Altered expression of circulating placental miRNA in maternal blood with pregnancy complication for potential application in noninvasive diagnosis.

Pregnancy complication	miRNA upregulated	miRNA downregulated	References
Preeclampsia	miR-210		[50]
		miR-376c	[19]
	miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, miR-574-5p		[65]
		miR-144	[47]
IUGR	miR-516-5p, miR-517, miR-518b, miR-520a, miR-520h, miR-525,; miR-526a		[39]
	miR-27a-1, miR-30d,; miR-93, miR-141,; miR-200c, miR-205,; miR-224, miR-335,; mir-424, miR-451, miR-491		[48]
Early pregnancy loss		miR-17, miR-19a; Found only on placental tissue; To be validated on maternal blood	[49]