Research Article
Effect of Long-Term Treatment with Fimasartan on Transient Focal Ischemia in Rat Brain
Figure 1
Schematic diagram of the study protocols. For Sprague-Dawley rats, low-dose (0.5 mg/kg) or regular doses (1 or 3 mg/kg) were administered for 4 weeks via an oral route before the induction of transient middle cerebral artery (MCA) occlusion. At 2 days, western blot (WB) analyses were performed. At 7 days immunofluorescent staining was performed, and infarct volume was measured. Behavior tests were performed for 14 days after induction of transient MCA occlusion, and mortality was censored at 28 days. Blood pressure was monitored during the pretreatment and follow-up period.