Prokineticin 2 Upregulation in the Peripheral Nervous System Has a Major Role in Triggering and Maintaining Neuropathic Pain in the Chronic Constriction Injury Model

Figure 11

Confocal images of representative skin sections immunostained for CGRP and NF200 from sham-operated, CCI-saline, and CCI-PC1 mice at 10 dpi. (a) In sham-operated mice the CGRP positive fibers were distributed along the dermoepidermal junction. (b) In CCI-saline mice the CGRP positive fibers were absent. (c) In CCI-PC1 mice the CGRP positive fibers were present in dermis. (d) In sham-operated mice the NF200 positive fibers were distributed along the dermoepidermal junction and in dermis. (e) In CCI-saline mice very few NF200 positive fibers were observed. (f) In CCI-PC1 mice the NF200 positive fibers were present in dermis. Dashed line represents the dermoepidermal junction. Scale bar 20 μm.

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