Prokineticin 2 Upregulation in the Peripheral Nervous System Has a Major Role in Triggering and Maintaining Neuropathic Pain in the Chronic Constriction Injury Model

Figure 6

Immunostaining of activated macrophages (CD11b+, red), S100β+ SC (red), and GFAP+ SC (red) in the neuroma from CCI-saline and CCI-PC1 mice ((a)–(h)). Repeated treatment with the PKR-antagonist significantly reduced the GFAP+ activated SC (i) but did not affect S100β+ SC or macrophage infiltration ((c), (f)).

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