Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in db/db Mice

Figure 6

The effect of MMF on apoptotic injury and NAD(P)H oxidase. The proapoptotic Bax and antiapoptotic Bcl2 were analyzed by western blotting (a) and quantitative analyses of the Bax/Bcl2 ratio (b). Tubulointerstitial TUNEL staining (c) and TUNEL-positive cells were assessed for quantitative analysis (d) in three experimental groups. Original magnification ×400. Representative western blot images of NADPH oxidase, NOX4, and p67phox are shown (e). The quantification of NADPH oxidase (f). The results are expressed as mean ± SE. , versus db/m; , versus db/db.

(a)

(b)

(c)

(d)

(e)

(f)