PFOS Disturbs BDNF-ERK-CREB Signalling in Association with Increased MicroRNA-22 in SH-SY5Y Cells

Figure 1

Effects of PFOS on SH-SY5Y cell viability and morphology. (a) Cell viability was determined by CCK8 assay after a 24- or 48-hour exposure to various concentrations of PFOS (1, 10, 50, 100, 150, and 200 μM) or DMSO (control). (b) SH-SY5Y cell morphology was observed after a 48-hour exposure to various concentrations of PFOS (10, 50, 100, 150, and 200 μM) or DMSO (control). Magnification, 200x. Data are presented as mean ± SD of three separate experiments. , experimental values compared with control values.

(a)

(b)