Mineral and Skeletal Homeostasis Influence the Manner of Bone Loss in Metabolic Osteoporosis due to Calcium-Deprived Diet in Different Sites of Rat Vertebra and Femur
Table 6
Dynamic histomorphometric parameters (Nf B Ar-MAR-MS) in middiaphyseal femoral sections.
Group
Round-shaped sections
Sharp-edge-shaped sections
Periosteal Nf B Ar (mm2)
Endosteal Nf B Ar (mm2)
Periosteal Nf B Ar (mm2)
Endosteal Nf B Ar (mm2)
2
0.27 ± 0.10
0.18 ± 0.15
0.82 ± 0.23
0.05 ± 0.06
3
0.23 ± 0.09
0.14 ± 0.09
0.77 ± 0.34
0.001 ± 0.001
4
0.20 ± 0.10
0.06 ± 0.04
0.80 ± 0.34
0.005 ± 0.012
Periosteal MAR (µm/day)
Endosteal MAR (µm/day)
Periosteal MAR (µm/day)
Endosteal MAR (µm/day)
2
2.38 ± 0.49
1.68 ± 0.92
3.67 ± 0.70
1.09 ± 0.99
3
2.82 ± 1.26
2.25 ± 0.55
3.65 ± 1.13
0.14 ± 0.32
4
2.56 ± 0.59
2.03 ± 1.09
3.84 ± 1.27
0.17 ± 0.37
Periosteal MS (%)
Endosteal MS (%)
Periosteal MS (%)
Endosteal MS (%)
2
52.40 ± 12.91
41.78 ± 18.95
67.39 ± 18.58
29.25 ± 19.06
3
54.89 ± 12.62
42.77 ± 21.83
84.45 ± 10.06
49.94 ± 16.52
4
62.81 ± 14.60
41.81 ± 5.19
72.26 ± 20.26
41.77 ± 7.07
All values are expressed as mean ± sd, ANOVA followed by Bonferroni’s test. Group 1: baseline; Group 2: control, normal diet; Group 3: calcium-deprived diet for 4 weeks; Group 4: calcium-deprived diet, plus concomitant administration of PTH (1-34) 40 µg/kg/day, for 4 weeks.
