Mineral and Skeletal Homeostasis Influence the Manner of Bone Loss in Metabolic Osteoporosis due to Calcium-Deprived Diet in Different Sites of Rat Vertebra and Femur
Table 9
Values of serum levels at the end of the experiments: Ca, P, OPG, BALP, CrossLaps, and PTH (1-84).
Group
Ca mg/dL
P mg/dL
OPG ng/ml
BALP ng/ml
CrossLaps ng/mL
PTH (1-84) pg/ml
1
10.02
7.38
0.75
7.12
38.67
41.24
10.42
5.87
0.67
7.22
59.76
40.65
10.34
7.63
0.72
6.78
73.86
33.59
Mean value ± sd
10.26 ± 0.21
6.96 ± 0.95
0.71 ± 0.04
7.04 ± 0.23
57.40 ± 17.71
38.49 ± 4.25
2
9.89
6.67
0.75
6.53
36.62
45.35
10.14
6.71
0.65
6.94
40.61
80.06
9.46
8.13
0.76
6.51
45.31
84.18
9.48
5.75
0.74
8.00
84.52
31.24
9.75
6.00
0.68
6.55
52.53
31.82
Mean value ± sd
9.74 ± 0.28
6.65 ± 0.92
0.71 ± 0.04
6.90 ± 0.63
51.91 ± 19.16
54.52 ± 25.85
3
9.78
7.00
0.69
6.74
52.77
61.82
10.10
6.55
0.60
6.33
86.80
79.47
10.18
8.78
0.67
7.28
58.20
98.29
9.90
6.86
0.57
6.59
83.06
39.47
10.11
7.57
0.85
7.26
51.01
115.35
Mean value ± sd
10.01 ± 0.16
7.35 ± 0.87
0.67 ± 0.10
6.84 ± 0.41
66.36 ± 17.20
78.88 ± 29.79
4
10.36
6.97
0.70
6.82
120.33
80.06
10.52
5.96
0.67
6.33
38.04
72.41
9.86
7.35
0.76
7.00
85.78
41.24
10.00
7.39
0.62
6.29
62.14
90.65
10.11
7.46
0.71
6.90
47.00
45.35
Mean value ± sd
10.12 ± 0.28
7.04 ± 0.72
0.69 ± 0.05
6.63 ± 0.37
58.24 ± 20.88
62.41 ± 23.35
ANOVA followed by Bonferroni’s test. Group 1: baseline; Group 2: control, normal diet; Group 3: calcium-deprived diet for 4 weeks; Group 4: calcium-deprived diet, plus concomitant administration of PTH (1-34) 40 µg/kg/day, for 4 weeks.
