Production of Monoclonal Antibodies in Plants for Cancer Immunotherapy
Table 2
Comparison between mammalian cell and plant systems.
Characteristics
Mammalian cells
Plants
Advantages
(i) Posttranslational modifications of proteins similar to the human (ii) Relatively high production capacity (easy collection and attractive yield)
(i) High production capacity (ii) Cost/attractive yield (iii) Increased viral safety (iv) Easy production (v) High uniformity of production through generation
Inconveniences
(i) Viral safety (species barrier) (ii) Risk of contamination (biological and physic chemical) (iii) Difficulty to grow
(i) Glycosylation and posttranslational modification (ii) Culture parameter being uncontrollable (iii) Risk of contamination (soil bacterium and pollen dissemination)