Modified Weekly Cisplatin-Based Chemotherapy Is Acceptable in Postoperative Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer

Table 1

Characteristics of patients.

Characteristic	Patients ()
Age (years)
<65	101 (86.3)
≥65	16 (13.7)
Gender
Male	112 (95.7)
Female	5 (4.3)
Primary site
Oral cavity	47 (40.2)
Oropharynx	19 (16.2)
Hypopharynx	41 (35.0)
Larynx	7 (6.0)
Others^*	3 (2.6)
Differentiation of tumor
Well differentiated	61 (52.1)
Moderately differentiated	48 (41.0)
Poorly differentiated	8 (6.8)
Pathologic staging
I	4 (3.4)
II	8 (6.8)
III	14 (12.0)
IV(a)	83 (70.9)
IV(b)	8 (6.8)
p16^INK4A
Positive	8 (44.4)
Negative	10 (55.6)
Detectable^†	18
Extracapsular spread
Positive	41 (35.0)
Negative	76 (65.0)
Regional lymph node involvement
<2	54 (46.2)
≥2	63 (53.8)
Microscopic resection margin status
Positive	53 (45.3)
Negative	62 (53.0)
Unknown^‡	2 (1.7)
Tumor emboli
Positive	55 (47.0)
Negative	60 (51.3)
Unknown^‡	2 (1.7)
Perineural invasion
Positive	64 (54.7)
Negative	51 (43.6)
Unknown^‡	2 (1.7)
Lymphovascular invasion
Positive	87 (74.4)
Negative	28 (23.9)
Unknown^‡	2 (1.7)

Others included two patients with carcinoma of unknown primary and one patient with nasal antrum cancer.
^†In our institution, p16 ^INK4A immunohistochemistry was checked since June 2012.
^‡These were the cases of two patients with carcinoma of unknown primary.