Gene Coexpression and Evolutionary Conservation Analysis of the Human Preimplantation Embryos

Table 1

Enriched biological process terms for stage-specific genes in preimplantation embryonic development. Similar function annotation clustering was presented by one typical function term. The last column stands for the validation of corresponding term in other studies of human preimplantation embryonic development.

Stage	Functional term	Bonferroni value	Consistence with previous report
Oocyte	DNA repair
	Cell cycle		[11, 12]
	DNA metabolic process
Zygote	Cell cycle		[12]
2-cell	Posttranscriptional regulation of gene expression
4-cell	Transcription		[11, 12]
	Regulation of transcription		[11, 12]
	Small GTPase mediated signal transduction		[11]
8-cell	DNA packaging
	RNA processing		[11]
	Transcription		[11, 12]
	Regulation of transcription		[11, 12]
	Translational elongation
	Ribonucleoprotein complex biogenesis		[12]
	RNA elongation
Morulae	RNA processing		[11]
	Transcription		[11, 12]
	Regulation of transcription		[11, 12]
	Ribonucleoprotein complex biogenesis		[12]
Late blastocyst	Generation of precursor metabolites and energy		[12]
	Translation		[12]
	Oxidative phosphorylation		[12]
	Cellular respiration		[12]
	Membrane organization
	Protein localization
	Cofactor metabolic process
	Protein transport
	Monosaccharide metabolic process