Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility
Table 3
Results of exploratory association analysis between the common AKT1 SNPs and smoking or cancer-related phenotypes.
SNP
CHRa
Positionb
Location
MAFc
Major/minor alleles
values for exploratory association analysis in genotypic/dominant/recessive models for each minor allele
Cancer status (present illness)
Cancer status (present or past illnesses)
Smoking history
Smoking period (year)
CPDd
Brinkman (smoking) index
rs4983556
14
104302924
3′-flanking
0.015
T/G
—
—
—
—
—
—
rs17846832
14
104309681
intron
0.0233
C/T
—
—
—
—
—
—
rs2498794
14
104316296
intron
0.4167
C/T
0.120/0.851/0.043
0.495/0.293/0.412
0.464/0.809/0.217
0.420/0.694/0.265
0.479/0.344/0.622
0.468/0.445/0.462
rs2494743
14
104322765
intron
0.4381
C/T
0.586/0.351/0.472
0.509/0.886/0.255
0.632/0.340/0.822
0.997/0.980/0.947
0.993/0.962/0.906
0.983/0.860/0.994
rs2498787
14
104327626
intron
0.4897
A/G
0.903/0.736/0.692
0.613/0.334/0.600
0.984/0.929/0.906
0.871/0.931/0.645
0.963/0.896/0.787
0.751/0.455/0.720
rs28546406
14
104333890
5′-flanking
0
G/G
—
—
—
—
—
—
rs4983387
14
104339273
5′-flanking
0.47
G/A
0.732/0.890/0.490
0.760/0.459/0.824
0.561/0.780/0.373
0.963/0.826/0.926
0.835/0.659/0.604
0.708/0.488/0.520
rs45478396
14
104343869
5′-flanking
0.0067
C/T
—
—
—
—
—
—
Chromosome number. bChromosomal position (bp). cMinor allele frequency. dCigarettes smoked per day. Significant association between the minor T allele of the SNP and cancer status (present illness) in the recessive model ().
