Table 3: Results of exploratory association analysis between the common AKT1 SNPs and smoking or cancer-related phenotypes.

SNP CHRa Positionb Location MAFc Major/minor allelesvalues for exploratory association analysis in genotypic/dominant/recessive models for each minor allele
Cancer status (present illness)Cancer status (present or past illnesses)Smoking historySmoking period (year)CPDdBrinkman (smoking) index

rs4983556141043029243′-flanking0.015T/G
rs1784683214104309681intron0.0233C/T
rs249879414104316296intron0.4167C/T0.120/0.851/0.0430.495/0.293/0.4120.464/0.809/0.2170.420/0.694/0.2650.479/0.344/0.6220.468/0.445/0.462
rs249474314104322765intron0.4381C/T0.586/0.351/0.4720.509/0.886/0.2550.632/0.340/0.8220.997/0.980/0.9470.993/0.962/0.9060.983/0.860/0.994
rs249878714104327626intron0.4897A/G0.903/0.736/0.6920.613/0.334/0.6000.984/0.929/0.9060.871/0.931/0.6450.963/0.896/0.7870.751/0.455/0.720
rs28546406141043338905′-flanking0G/G
rs4983387141043392735′-flanking0.47G/A0.732/0.890/0.4900.760/0.459/0.8240.561/0.780/0.3730.963/0.826/0.9260.835/0.659/0.6040.708/0.488/0.520
rs45478396141043438695′-flanking0.0067C/T

Chromosome number.
bChromosomal position (bp).
cMinor allele frequency.
dCigarettes smoked per day.
Significant association between the minor T allele of the SNP and cancer status (present illness) in the recessive model ().