Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility
Table 4
Results of confirmatory association analysis between the rs2498794 SNP and smoking or cancer-related phenotypes.
SNP
Stage
Pvalues for confirmatory and combined association analyses in genotypic/dominant/recessive models for each minor allele
Cancer status (present illness)
Cancer status (present or past illnesses)
Smoking history
Smoking period (year)
CPDa
Brinkman (smoking) index
rs2498794
confirmatory
0.208/0.453/0.077
0.075/0.903/0.038
0.552/0.892/0.336
0.143/0.743/0.092
0.912/0.890/0.744
0.141/0.733/0.092
rs2498794
combined
0.910/0.665/0.890
0.205/0.482/0.190
0.901/0.824/0.763
0.068/0.641/0.048†
0.610/0.529/0.610
0.073/0.486/0.070
Cigarettes smoked per day. Significant association between the minor T allele of the SNP and noncancer status (present or past illness) in the recessive model (). †Significant association between the minor T allele of the SNP and longer periods of smoking history in the recessive model ().