Effects of PMA (PHORBOL-12-MYRISTATE-13-ACETATE) on the Developing Rodent Brain

Figure 6

Cresyl violet staining (magnification 20x) performed in 10 μm-thick sections depicting disorganized cytoarchitecture of layers I and II of the frontal cortex in 14-day-old rats subjected to vehicle (a) or PMA (500 μg/kg) (b) at P6. 14- and 21-day-old rat pups treated with PMA at P6 showed reduced total cell density in comparison with controls (c) (–11 per group). Values are presented as mean ± SEM. ; , one-way analysis of variance (ANOVA) with Newman-Keul post hoc test.

(a)

(b)

(c)