Effects of PMA (PHORBOL-12-MYRISTATE-13-ACETATE) on the Developing Rodent Brain

Figure 7

Mice deficient in IRAK-4 or IL-18 are protected against PMA-induced neurodegeneration. Six-day-old homozygous IRAK-4 and IL-18 mice were subjected to PMA (200 μg/kg). Quantification of cell death was performed on fluoro-jade B-labeled sections. IL-18 (−/−) () and IRAK-4 (−/−) () deficient mice displayed significant differences in degenerating cells compared with their wild-type littermates (). PMA induced a strong neurodegenerative response in wild-type mice compared to their vehicle treated littermates. Values are presented as mean ± SEM. , one-way analysis of variance (ANOVA) with Newman-Keul post hoc test.