Effects of PMA (PHORBOL-12-MYRISTATE-13-ACETATE) on the Developing Rodent Brain

Table 1

Average weight gain in g/day, % survival rate and number of animals used.

Age	P3		P7		P7		P7		P14
Treatment; g/kg	PMA; 500	NaCl	PMA; 100	NaCl	PMA; 200	NaCl	PMA; 500	NaCl	PMA; 500	NaCl
Average weight gain; g/day	1.0 ± 0.2	1.3 ± 0.1	1.0 ± 0.2	1.4 ± 0.2	1.3 ± 0.2	1.4 ± 0.2	0.5^**  ±  0.1	1.4 ± 0.2	0.7^***  ±  0.1	2.8 ± 0.2
% survival	100	100	88	100	100	100	91	100	100	100
	11	10	7	8	9	8	10	8	8	5

P7 and P14 rats treated with PMA 500 g/kg showed impaired weight gain 24 hours after injection compared to their control littermates (±SEM, ; , Student’s -test).