New Insights into Glomerular Parietal Epithelial Cell Activation and Its Signaling Pathways in Glomerular Diseases

Table 2

Signaling pathways involved in glomerular parietal epithelial cells activation.

	Human	Animal model
Notch	FSGS, DN [46]	Collapsing FSGS transgenic mice model [44], FSGS SCID mice model [46]
Wnt/β-catenin	N/A	Conditional β-catenin −/− mice [57]
HB-EGF/EGFR	CGN, FSGS [60, 61]	Anti-GBM induced CGN mice model [62]
CXCR4/SDF-1	CGN [63]	MWF rat with CGN [64], VHL −/− mice [65]
Ang II//AT1 receptor	Proliferative CGN [64]	MWF rat with CGN [75]
LAT2	N/A	Anti-GBM induced CGN rat model [78]
SSeCKS/cyclin D	N/A	SSeCKS −/− mice [82]