Research Article

Three-Dimensional Modelling inside a Differential Pressure Laminar Flow Bioreactor Filled with Porous Media

Figure 1

(a) Schematics of differential pressure laminar flow bioreactor system with integrated laser-based oxygen sensor system (from PCT/EP2011/067344/WO 2012/045756). 1: Control box, 2: pressure ports, 3: bioreactor vessel with scaffold holder, 4: integrated bypass system, 5: sampling probe (for medium analysis), 6: culture medium reservoir, 7: peristaltic pump, 8: laser light with filters and lenses, 9: photomultiplier (light detector), 10: temperature sensor, 11: OPAL system with built-in sinusoidal frequency generator and lock-in amplifier, 12: computer with software, and: medium flow direction. (b) Photo of system. (c) Scaffold holder suitable for cultivation of up to seven cylindrical scaffolds.
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