Research Article
Three-Dimensional Modelling inside a Differential Pressure Laminar Flow Bioreactor Filled with Porous Media
Figure 3
CFD simulation of pressure distribution inside the bioreactor with scaffold permeability of (a) 10−11 m2, (b) 10−12 m2, and (c) 10−13 m2 and closed bypass system demonstrates pressure build-up in the upper part of the culture vessel by decreasing scaffold permeability due to cell growth. Pressure can be released by opening the integrated bypass system (d) (here shown for permeability m2), which results in approximation of pressure values for the upper and lower part of the culture chamber of the bioreactor.
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