Research Article

Surgical Treatment and Prognosis of Angiosarcoma of the Scalp: A Retrospective Analysis of 14 Patients in a Single Institution

Table 2

A review of literatures.

AuthorsYearM (F)Age at DxRaceLocation of tumorTreatmentSurgical methodMean f/u period
(months)
5-year
OSR (%)
5-year
DFSR (%)
2-year
OSR (%)
2-year
DFSR (%)
MS
(months)

1Hodgkinson et al. [12]1979137 (6)66 (51–80)NRHead and neckS (5), S + RT (5), RT (3)NR13
(1–96)
NRNRNRNRNR

2Holden et al. [4]19877244 (28)74 (56–92)CScalp and faceS + RT (3), RT (69)NRNR
(12–144)
12NR29NR15

3Mark et al. [7] 19962821 (7)61 (6–83)NRHead and neckS (12), S + CT (3), S + RT ± CT (6), RT ± CT (7)NR32
(3–159)
NR26NRNRNR

4Lydiatt et al. [6]19941813 (5)67C (17)Head and neckS (6), S + RT (2), S + CT (1), CT (9)NRNR3320NRNRNR

5 Morrison et al. [19]1995148 (6)66 (49–83)CScalp and faceS + RT (6), RT (3), S ± RT ± CT (11)STSGNR29NRNRNR22

6Pawlik et al. [11]20032918 (11)71 (33–90)C (28),
A (1)
ScalpS + RT (28), RT (1)WE, LF (2), and STSG (26)18.3
(3.2–106)
12NRNRNR28.4

7Ohguri et al. [20]20052011 (9)71 (49–91)A (J)ScalpRT + ITNR29.5
(5–120)
NRNRNRNR36.2

8Buschmann et al. [16]20081914 (5)77 (59–86)NRScalpS ± RT ± CTOc + STSGNRNRNRNRNR17.2

9 Köhler et al. [21]20082311 (12)63 (12–75)C (19), AA (3), and
A (1)
Head and neckS + RT (19), S + CT (2), S + RT + CT (2) WE (2 cm)19.7
(5–108)
21.7NRNRNRNR

10Lim et al. [22]201095 (4)71 (64–82)A (K)ScalpS ± RT (8)WE (5 cm) + Oc + LD + STSG + Pr + Nd24NRNRNR10015

11 Ogawa et al. [23]20124829 (19)77 (58–94)A (J)Scalp and faceS + RT ± CT ± IT (17), S + CT + IT (2), RT ± CT ± IT (20), RT (5), and IT (4)WE (3–5 cm)13.7
(2.5–105.9)
NRNR22.1NR13.4

12 Dettenborn et al. [24]20148050 (30)71
(SD 14.4)
NRHead and neckS (32), S + RT (38), S + CT (4), and S + RT + CT (6) NR55.3
(SD 74.4)
54NR71NR64.0
(CI 48.4–75.6)

13 Mullins and Hackman [5]201565 (1)66 (52–83)C (4), AA (2)Head and neckS (1), S + RT (2), S + RT + CT (1), and C (2) NR42NRNRNR2036.7
(5–76)

14Patel et al. [14]20155539 (16)NRNRScalp and faceS ± RT ± CT (39)NR25.2
(4.7–227.1)
3816NRNR25.2

15Our study20151413 (1)69 (52–81)A (K)ScalpS (3), S + RT (3), S + CT (3), and S + RT + CT (5)WE (1–5 cm)17
(8–87)
157.77538.731
(CI 27.0–37.0)

Year: year of publication; : number of patients; M: number of male patients; F: number of female patients; Dx: diagnosis; f/u: follow-up; OSR: overall survival rate; DFSR: disease-free survival rate; MS: medial survival; SD: standard deviation; NR: not recorded; C: Caucasian; AA: African American; A: Asian; K: Korean; J: Japanese; S: surgery; RT: radiation; CT: chemotherapy; IT: immunotherapy; +: and; ±: and/or; STSG: split-thickness skin graft; WE: wide excision; LF: local flap; LD: reconstruction using a free latissimus dorsi muscle flap; Oc: outer corticotomy of the calvarium; Pr: ipsilateral parotidectomy; Nd: ipsilateral neck dissection; cm: resection margin in centimeters; CI: 95% confidence interval.