Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors

Table 4

Multiple linear regression analysis of cIMT with selected clinical features.

Independent variables	cIMT
	Model 1		Model 2		Model 3
	Age, years	0.002	0.09	0.005	0.12	0.001	0.71
Disease duration, years	−0.002	0.44	−0.008	0.24	−0.004	0.29
CRP, mg/L	0.006	0.05	0.008	0.05	0.008	<0.001
Anti-CCP, U/mL	0.001	0.005	0.001	0.009	0.001	0.03
RF, IU/mL	—	—	0.005	0.93	0.003	0.43
DAS28, units	—	—	−0.019	0.20	−0.046	0.08
TNFα, pg/mL	—	—	—	—	0.001	0.67
IL-6, pg/mL	—	—	—	—	0.003	0.05
	0.87	<0.001	0.86	<0.001	0.89	<0.001

cIMT, carotid intima-media thickness; CRP, C-reactive protein; anti-CCP, anticyclic citrullinated peptide antibodies; RF, rheumatoid factor; DAS28, disease activity score; TNF, tumor necrosis factor , IL-6, interleukin-6; , multiple coefficient of determination; , standard regression coefficient.