Reference Study groups and design CVD risk factors present in studied patients Anti-CCP/IL-6/TNF Conclusions
del Rincón et al. (2003) [16 ] Cross-sectional Age ≥40 yrs old No ESR, CRP, and RF being associated with the increased cIMT in RA patients
Gerli et al. (2005) [22 ] Cross-sectional Systemic hypertension, dyslipidemia, type 2 DM, current smokers, and family history of CVD No Smoking increasing the cIMT in RA patients
Hannawi et al. (2007) [23 ] Cross-sectional Current smokers No Higher cIMT in RA than HC; cIMT correlating with DAS28 and CRP; atherosclerotic plaques being more frequent in RA
Ciftci et al. (2008) [24 ] Cross-sectional None No Increased cIMT in RA versus HC; correlation between cIMT and time of evolution
Stamatelopoulos et al. (2009) [25 ] Cross-sectional None No Increased cIMT in RA versus HC
Ristić et al. (2010) [26 ] Cross-sectional Current smokers Anti-CCP Higher cIMT in RA smokers; negative correlation with time on treatment; positive correlation with FR and ESR
Ahmed et al. (2010) [27 ] Cross-sectional None No DAS28, ESR, CRP, disease duration, steroids use, and ox-LDL associated with the presence of plaque
Södergren et al. (2010) [4 ] Cross-sectional Current smokers, family history of CVD No Higher cIMT in RA versus HC
El-Barbary et al. (2011) [28 ] Cross-sectional None IL-6 Positive correlation between anti-MCV with changes in cIMT, not with anti-CCP
Ajeganova et al. (2012) [29 ] Prospective cohort RA None No Higher cIMT associated with CRP
Targońska-Stepniak et al. (2011) [30 ] Cross-sectional Type 2 DM, Systemic hypertension Anti-CCP Higher cIMT associated with age, anti-CCP, erosions, and extra-articular manifestations
Akrout et al. (2012) [31 ] Cross-sectional None No Higher cIMT in RA than control; higher AIP in RA and lower HDL
Vázquez-Del Mercado Mónica (Present study)
Cross-sectional None Anti-CCP Levels of anti-CCP and CRP associated with the cIMT in RA in multiple linear regression
