Review Article

Non-VKA Oral Anticoagulants: Accurate Measurement of Plasma Drug Concentrations

Figure 3

Impact of apixaban on prothrombin time (PT). There is a linear concentration-dependent prolongation of PT. The sensitivity highly depends on the reagent. PT is not sensitive enough to estimate plasma drug concentrations of apixaban or to assess the relative intensity of anticoagulation at therapeutic doses (±100 ng/mL at in healthy subject taking apixaban 5 mg bid) [56] (adapted from Douxfils et al. [55]).