DNA Methylation and Histone Modifications Are the Molecular Lock in Lentivirally Transduced Hematopoietic Progenitor Cells

Figure 6

GFP expression of HPCs transduced with LV/CMV/GFP and treated either with 2 μM 5-azaC + 50 nM TSA (Cocktail 1) or with 2 μM 5-azaC + 150 nM TSA (Cocktail 2) to prevent and to reverse GFP silencing. The expression was measured at day 5 after transduction. Untreated cells were served as the control. Data are presented as mean ± standard deviation in triplicate. Statistical difference between groups compared to the transduced untreated group is reported as .