DNA Methylation and Histone Modifications Are the Molecular Lock in Lentivirally Transduced Hematopoietic Progenitor Cells

Table 2

Summary on the methylation and chromatin status of the CMV promoter and GFP transgene during the lowest and the highest GFP expression.

(a)

Day 2; Highest GFP Expression	CMV Promoter	GFP Transgene
Chromatin Status	Acetylated/Euchromatic	Acetylated/Heterochromatic
Methylation status	Methylated

(b)

Day 7; Lowest GFP Expression	CMV Promoter	GFP Transgene
Chromatin Status	Acetylated/Heterochromatic	Deacetylated/Heterochromatic
Methylation status	Methylated