The Roles of SNF2/SWI2 Nucleosome Remodeling Enzymes in Blood Cell Differentiation and Leukemia

Figure 1

Classification of SNF2 enzymes and schema of mammalian hematopoiesis. SNF2-like chromatin remodelers belong to SF2 superfamily and are classified based on conserved structure of the ATPase domain as discussed in Flaus et al. [5] (a). Overview of mammalian hematopoietic cell development and differentiation. Dashed arrows show intermediate stages of hematopoietic development which is not shown in the figure for simplicity purpose (b).

(a)

(b)